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Remco Peters, a clinical programme specialist at Anova Health Institute, presented findings from a cohort study on tuberculosis (TB) testing at the TB conference held in Durban last week. The study was conducted at 5 primary healthcare (PHC) facilities in Mopani District, comparing clinic versus remote laboratory basedXpert® MTB/RIF for diagnosis of tuberculosis (TB) in rural South Africa. This TB test provides accurate data within two hours so that patients can be offered proper treatment on the same day. See the full presentation together with its findings below: Downloads:  A cohort study of clinic versus laboratory based Xpert A presentation by Remco Peters from Anova

Anova\’s Remco Peters, a clinical programme specialist, together with Erik Schaftenaar, a PhD student doing research with Anova, recently conducted a study on seroprevalence of Human Herpesviruses (HHVs) in Rural South Africa. The study in Mopani District (a rural area in Limpopo) found high seroprevalence of HHVs in HIV-infected people attending primary healthcare facilities in rural South Africa. Anova would also like to acknowledge the Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands, in their collaboration with Anova on this interesting and informative report. Seroprevalence data of human herpesviruses (HHVs) are limited for sub-Saharan Africa. These are important to provide an indication of potential burden of HHV-related disease, in particular in human immunodeficiency virus (HIV)-infected individuals who are known to be at increased risk of these conditions in the Western world. In this cross-sectional study among 405 HIV-infected and antiretroviral therapy naive individuals in rural South Africa the seroprevalence of HHVs was: herpes simplex virus type 1 (HSV-1) (98%), herpes simplex virus type 2 (HSV-2) (87%), varicella zoster virus (VZV) (89%), and 100% for both Epstein-Barr virus (EBV) and cytomegalovirus (CMV). Independent factors associated with VZV seropositivity were low educational status and having children. Lack of in-house access to drinking water was independently associated with positive HSV-1 serostatus, whereas Shangaan ethnicity was associated with HSV-2 seropositivity. Increasing age was associated with higher IgG titres to both EBV and CMV, whereas CD4 cell count was negatively associated with EBV and CMV IgG titres. Moreover, IgG titres of HSV-1 and 2, VZV and CMV, and CMV and EBV were positively correlated. The high HHV seroprevalence emphasises the importance of awareness of these viral infections in HIV-infected individuals in South Africa. In a recently published ANC survey on HSV-2 prevalence in four provinces (not Limpopo though), prevalence was in a similar range for HIV-infected individuals, but much higher than among those without HIV infection. The study, High Seroprevalence of Human Herpesviruses in HIV-Infected Individuals Attending Primary Healthcare Facilities in Rural South Africa, which was published in a science journal Plos One, is available for you to read below: Downloads:  High Seroprevalence of HHVs in HIV-Infected Individuals Attending PHC Facilities in Rural SA A study conducted by Remco Peters and Eric Schaftenaar

Last year Anova has seen a reshaping of priorities and a renewed focus on sustainable support of the SA government\’s leadership on HIV and AIDS. We have seen huge strides in health systems strengthening activities, including increased effort in clinical mentorship and effective data collection. It has been a productive and innovative year. Read more on what 2013 has meant for Anova and the health sector.   Downloads:  Annual Report 2013 PDF version

Two accepted publications about the work done on side-effects in HIV-infected children on antiretroviral treatment (ART) in Mopani were recently published. You can access the study done on lactate levels here, and the neuropathy manuscript. To read the full study you need to subscribe to the relevant journals. In one recent case study conducted by Anova, led by clinical programme specialist, Remco Peters, on the side-effects of ART in children, interesting findings were made around prepubertal gynecomastia. It was the first reported case of prepubertal gynecomastia in a young girl attributed to efavirenz use. Prepubertal gynecomastia is a rare condition and most frequently classified as idiopathic. The study looked at a seven-year-old African girl presented with true gynecomastia four months after initiation on ART (abacavir, lamivudine, efavirenz). History, physical examination and laboratory tests excluded known causes of gynecomastia and efavirenz was considered as the most likely cause. Six weeks after withdrawal of efavirenz the breast enlargement had completely resolved. In HIV-infected adults gynecomastia is a recognised but infrequent side-effect of ART and mostly attributed to efavirenz use. In the medical literature only five cases of prepubertal gynecomastia in children taking ART are described and underlying pathogenesis was unknown. The occurrence of adverse effects of ART may interfere with therapy adherence and long-term prognosis and for that reason requires attention. Read the full research report below:  Case study

Dr Andrew Tucker from Anova spoke at the SAfAIDS tweetable dialogue on April 3 forming part of their rock leadership programme, which seeks to promote access to integrated SRH and HIV services for key populations in East and Southern Africa. Dr Kevin Rebe from Health4Men was also involved in putting the presentation together.Dr Tucker’s presentation focused on Homophobia and MSM Health and showed that through their recent research with Health4Men, an Anova project, that we can now see a scientific chain from homophobia to poor health outcomes for men who have sex with men (MSM). Health4Men project which is dedicated to addressing this heightened HIV risk through the provision of competent, prejudice-free sexual healthcare for MSM and the promotion of a sex-positive attitude among healthcare workers.The purpose of the Tweet@ble Regional Policy Dialogue is to explore policy options for strengthening sexual and reproductive health services access and uptake in reducing the burden of HIV among key populations in east and southern Africa. It is also hope that it will generate practical recommendations for policy on how to address SRH and HIV concerns for key populations in the post 2015 development agenda.Running under the theme: “Guaranteeing SRHR for Key Populations in the Post-2015 Development Agenda: A call for Leadership and Accountability for Improved Health Outcomes in ESA”, the dialogue was attended by representatives of the African Union, SADC, Key populations, civil society organisations, National AIDS Councils, relevant Ministries and funding agencies. The Former President of Mozambique, Joaquim Chissano also attended.The dialogue forms part of the SAfAIDS rock leadership programme, which seeks to promote access to integrated SRH and HIV services for key populations in the region.  Join the dialogue on SAfAIDS Twitter,#SRHRkeypops or Stay Connected on SAfAIDS Facebook Page.You can follow Anova and Dr Tucker on Twitter.Read Dr Tuckers’ SAfAIDS presentation below.  Downloads:  Homophobia and MSM healthHealth4Men’s approach to homophobia and men who have sex with men (MSM)