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In April 2025, Anova Health Institute launched a strategic partnership with the HCI Foundation, the corporate social investment arm of Hosken Consolidated Investments (HCI). The collaboration supports the project “Access to Pre-Exposure Prophylaxis (PrEP) for Young People in Limpopo Province.” The initiative focuses on adolescent girls and young women, who remain at especially high risk of HIV. Building on Anova’s technical expertise and HCI’s commitment to social impact, the partnership aims to strengthen youth-friendly HIV prevention services in Polokwane Sub-District, Capricorn District — a youthful hub that is home to the University of Limpopo, two TVET colleges, and several private colleges. Key activities include deploying youth ambassadors to engage peers, training Department of Health staff to integrate PrEP into routine care and expanding facility- and community-based outreach. With more than 8,200 adolescent girls and young women already initiated on PrEP in Limpopo over the past year, the project is well positioned for rapid scale-up in this high-impact area. The project marks the beginning of a collaboration with strong potential for growth, enabling Anova and HCI to expand reach and build sustainable impact in HIV prevention for young people.

Please join us in congratulating Dr. Diana Mokoena on her appointment to the Anova Health Institute Board of Directors. Diana served as an Invitee to the Board’s Social and Ethics Committee for more than a year and now formally joins the Board, bringing over a decade of experience at Anova and a deep commitment to strengthening public health in South Africa. Since joining Anova in 2014 as a Clinical Advisor, Diana has held several senior roles, including Programme Manager for Johannesburg and, since 2021, Senior Head of Division: Programme Implementation. In 2024, she was appointed Chief of Party for our USAID PEPFAR APACE (Accelerating Programme Achievements to Control the Epidemic) award, where she led a team of more than 3,000 staff, overseeing innovative HIV and TB programmes in partnership with the Department of Health. Her appointment reflects Anova’s commitment to drawing on strong internal leadership, technical excellence, and lived institutional experience to guide the organisation’s future. We are proud to welcome Diana to the Board and look forward to her continued contributions.

South Africa remains at the epicentre of the HIV epidemic, but a game-changing tool is coming. Lenacapavir, the world’s first twice-yearly HIV prevention injection, has been approved by the South African Health Products Regulatory Authority (SAHPRA) — a major step toward making it available in public clinics from April 2026. Lenacapavir, developed by Gilead Sciences, is a long-acting antiretroviral that provides six months of protection against HIV with a single injection. Clinical trials have shown it to be among the most effective prevention options available, offering a discreet and convenient alternative to daily PrEP pills. Its long-acting nature could overcome many of the adherence challenges associated with daily oral PrEP, making it especially valuable for young people and key populations who face barriers to consistent pill-taking. The South African government, with R520 million in Global Fund support, plans to begin a phase-one rollout across 23 high-incidence districts in six provinces, targeting around 360 clinics and up to 456,000 people in the first two years. Minister of Health Dr. Aaron Motsoaledi affirmed the government’s commitment to make lenacapavir “a public good — accessible, affordable, and locally produced.” With many years of experience in PrEP delivery, key population programming, and health systems strengthening, Anova Health Institute looks forward to supporting the rollout of this breakthrough prevention tool and ensuring equitable access for those who need it most. Header image: © Gilead Sciences

We are proud to share that Dr. Kate Rees, Public Health Specialist at Anova, co-chaired the 12th SA AIDS Conference together with Dr. Candice Chetty from HE²RO. Held under the theme “Unite for Change – Empower Communities and Redefine Priorities for HIV/AIDS”, the conference brought together leaders, researchers, implementing partners, academics, and advocates from around the world to reflect on the evolving landscape of HIV care and prevention. With the introduction of South Africa’s National Health Insurance (NHI), the emergence of long-acting therapies, and shifting global political dynamics, this year’s gathering came at a pivotal moment in the HIV response. In addition to Dr. Rees’s leadership role, Anova had a strong scientific presence, with staff and collaborators presenting on diverse aspects of HIV prevention, treatment, and health systems innovation, including: Collaboration framework for working with traditional healer practitioners (THPs) in HIV services — Cathrine Chinyandura Using co-creation to develop a paediatric case management toolkit: description of an intersectoral process — Dr. Carol Tait Breaking barriers: Integrating HIV testing services into men’s daily routines to enhance testing uptake in Johannesburg Health District — Norma Tshabalala Higher viral suppression rates in a cohort of patients initiated on ART via index testing in Sedibeng district — Chipo Mutyambizi, PhD Programmatic description of PrEP service linkage to HIV-uninfected pregnant women in Cape Town Metropole facilities — Cristal Solomons Breaking down mental health care barriers to promote SRH service utilization amongst adolescent girls and young women in rural communities — Enock Zibengwa, PhD Anova staff also contributed more than 11 additional posters, covering a wide range of topics and highlighting the organisation’s technical expertise and collaborative approach.

The Board of Directors of the Anova Health Institute NPC is pleased to announce the appointment of Dr Moyahabo Mabitsi as Joint Chief Executive Officer of Anova with effect from April 2024. Dr Mabitsi, who will join Dr Helen Struthers as Joint CEO, has many years’ experience in leading large grant-funded public health programmes in South Africa. She has been a member of Anova’s Board since 2018. Dr Struthers will be stepping down from the Anova CEO position at the end of 2024, on reaching retirement age. She remains committed to the success of the organisation. The Board also welcomes the appointment of Dr Diana Mokoena as Chief of Party of the PEPFAR/USAID funded APACE grant. This is one of the largest and most complex PEPFAR programmes in the world. Dr Mokoena will lead a dedicated team of experienced programme and technical specialists. Both Dr Mabitsi and Dr Struthers will continue to provide technical and management expertise to all Anova’s activities, including the APACE programme. Since 2009, as one of the founders and Chief Operations Officer of Anova, Dr Struthers led the PEPFAR/USAID and other grant funded public health implementation programmes as Chief of Party. During this time Anova grew to be one of the largest and most successful Health NGOs in Africa. After Dr Struthers stepped into the CEO position, Dr Mabitsi took on the role as Chief of Party and Chief Medical Director. This announcement is the culmination of a multiyear succession plan which builds on Anova’s strengths and advances our transformation strategy. We have every confidence in Dr Mabitsi’s ability to lead the organisation and ensure the seamless transition of the CEO role. Dr Mabitsi and Dr Mokoena are shining examples of Anova’s commitment to develop and nurture our internal talent. They have demonstrated their commitment and ability in leading a range of Anova’s health programmes. Ms Faith Mayimela-Hashatse Board Chair Ends   For more information, please contact: Sibonisiwe Dube Head of Marketing, Anova Health Institute Tel +27 11 581 5007 info@anovahealth.co.za www.anovahealth.co.za

Fear and anxiety have gripped the globe in the past 19 months as COVID-19 took a toll on life, economies and society at large. The pandemic affected our lives in ways we could’ve never imagined, not only did it impact our finances, but it has taken a toll on some people’s mental health too. The World Health Organisation defines mental health as “a state of well-being in which every individual realizes his or her own potential, can cope with the normal stresses of life, can work productively and fruitfully, and is able to make a contribution to her or his community.” Everyone must try to cope with stress at some point in time.  A certain amount of stress isn’t necessarily a bad thing, but too much stress can overwhelm a person’s ability to cope. In the long term it becomes harmful to our physical and mental health, sometimes reaching a point where our mood, thinking and behaviour is affected. Depression and anxiety are common mental disorder that can be triggered, among other things, by chronic stress that endures over a long period. Severe stress, caused by negative life events, such as a divorce or financial loss, or loss of loved ones during the pandemic, puts the psyche out of balance, therefore it’s vital that stress is managed properly. Already, one in three South Africans suffers from depression and rates are climbing. As we commemorate World Mental Health Month, we are urging you to put yourself first and practise self-care. If you are worried or wondering about your mental health or think you are at risk of developing a mental health disorder, here are some common warning signs you should look out for: Early Warning Signs Dr Tamsyn Nash, a Counselling Psychologist at Witkoppen Health and Welfare Centre says that experiencing one or more of the following feelings or behaviours can indicate a problem: Eating or sleeping too much or too little Pulling away from people Having low or no energy Feeling numb or like nothing matters Having unexplained aches and pains Feeling helpless or hopeless Feeling unusually confused, forgetful, on edge, angry, upset, worried, or scared Yelling or fighting with family and friends Experiencing severe mood swings that cause problems in relationships Thinking of harming yourself or others If you’re feeling one or more of the symptoms mentioned above, you may need to seek professional help. But what if you can’t afford it? Here few techniques you could try: If you feel yourself sinking, give yourself time to just be.  Give yourself one day to just feel whatever you are feeling. It’s okay, we’re all human. Negative emotions are valid. Relaxation exercises such as breathing and meditation can be helpful for coping with anxiety. Exercising can help lighten up your mood, try jogging or walking around the block. Talk to someone you can trust. Talking about your feelings within a safe space with someone who’s non-judgemental allows you to express what you feel instead of ignoring or suppressing it. Say NO more often. Learning the art of saying “no”  identifying and expressing your needs is helpful, especially when your anxiety stems from taking on more than you can handle. Mental health is as important as physical health. Mental illness should be taken seriously and not to be ignored. Take care, watch for the signs. Your wellbeing is important! Here are a few helpful numbers you can contact should you need to: Suicide Crisis Line:0800-567-567 Lifeline:086-132-2322 Domestic violence helpline:0800-150-150 Childline:0800-055-555 Mental Healthcare for All: Let’s make it a reality

23 February 2024 [Johannesburg, South Africa]   The Anova Health Institute is proud to announce the receipt of a substantial grant from the United States Agency for International Development (USAID), following a rigorous and competitive application process, a testament to our commitment to healthcare excellence and innovation. With support from the U.S. Government through the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR), and programmatically through USAID, the Anova Health Institute will partner with the Limpopo Department of Health to implement the new award, “Achieving and Sustaining HIV/TB epidemic control in Limpopo Province”. The aim of this new five-year award is to support efforts towards HIV/TB epidemic control in Capricorn and Mopani districts. The Limpopo provincial government has termed this award ‘Hanyani Bophelo programme’ which means “live life”. This ambitious programme will be led by Dr. Lucy Ranoto, a medical professional with over ten years’ experience in the HIV/TB response in Limpopo. The programme builds upon Anova’s two-decade history of successful, impactful partnerships with the Limpopo Department of Health. Dr. Moyahabo Mabitsi, Anova’s Chief Medical Director, expressed optimism and commitment: “Our enduring collaboration with USAID and the Department of Health reflects Anova’s dedication to improving health outcomes. The Hanyani-Bophelo programme is poised to make a significant impact in the communities we serve. Throughout our journey, Anova’s mission has been to enhance people’s lives and expand access to quality healthcare by developing innovative solutions, building on scientific evidence and fostering productive partnerships. This generous grant will enable us to take a significant step forward in realising Anova’s vision of excellent health for all.” USAID Southern Africa Regional Mission Director, Leslie Marbury said, “The U.S. government’s support in South Africa reflects an enduring commitment to improve the well-being, prosperity, and quality of life of individuals and communities. With a focus on ending TB and HIV, our PEPFAR program catalyses transformative change, aligning with the South African government’s vision. Together, we forge pathways to healthier communities and brighter futures, grounded in partnership, innovation, and compassion.” In response to this grant, Dr Mutheiwana Dombo, Deputy Director General (DDG) of the Department of Health in the Limpopo Province has shown her gratitude, “This PEPFAR grant to our partner Anova Health Institute is a welcome development. Through close collaboration with Anova we have made positive strides towards the fight against HIV/AIDS, and we believe that this grant will enable both parties to continue on this journey.”   About the Anova Health Institute: The Anova Health Institute is a renowned healthcare NGO, at the forefront of the global battle against HIV. Recognised for its innovative and impactful approaches, Anova is making strides in increasing access to quality HIV care and treatment within the public sector. Our work in this field is not just about providing services; it’s about pioneering new ways to tackle the HIV epidemic. Our expertise extends across various critical areas: from clinical management of HIV to focusing on key populations and conducting comprehensive research on both clinical and social aspects of HIV. This multi-faceted approach enables Anova to not just respond to the HIV crisis but to actively shape the strategies and solutions that lead the way in this field. With a deep commitment to innovation and excellence, Anova is leading the charge in transforming HIV care and treatment. As one of the largest global partners of the PEPFAR programme, Anova plays a critical role, currently supporting nearly a million individuals on antiretroviral treatment through the Department of Health services in South Africa.   Media Contact: Sibonisiwe Dube Head of Marketing, Anova Health Institute 060 560 2673 info@anovahealth.co.za For more information, visit us on: www.anovahealth.co.za Facebook: Anova Health Institute Twitter: @AnovaHealthSA LinkedIn: Anova Health Institute

In a significant stride towards achieving UNAIDS targets, Anova Health Institute has launched the ARVs4Me campaign, reinforcing its commitment to the global effort of ending the HIV/AIDS epidemic. UNAIDS set ambitious goals, urging for 95% of people living with HIV to know their status, 95% of those diagnosed to be on antiretroviral treatment, and 95% of those on treatment to achieve viral suppression by 2025. The ARVs4Me campaign, initiated at the beginning of November, serves as a catalyst to encourage communities to actively participate in reaching these targets. Operating in areas mostly affected by HIV, the aim of the campaign is to communicate the benefits that come with having a virus that is controlled and suppressed due to antiretroviral treatment, which include, living an active life where one is able to work, study, take care of loved ones and “ do life’ without worrying about being sick or visiting the clinic multiple times to collect HIV medication. The emphasis is also on the ease and convenience of taking the current treatment regimens which mostly comprise of 1 pill a day with minimal to no side effects. Anova Health Institute recognises the vital role of community engagement in achieving these targets. The campaign involves direct interactions with individuals affected by HIV, providing a platform for them to share their lived experiences. By amplifying these voices, Anova aims to promote testing for HIV, motivate adherence to medication and encourage restarting treatment for those who have stopped taking it. The launch of the ARVs4Me campaign holds particular significance as it coincides with the global commemoration of World Aids Day, celebrated under the theme \”Let communities lead.\” This annual observance not only highlights the genuine experiences of those currently living with HIV but also honours the unwavering strength, resilience, and diversity within the communities most affected. Dudu Mdletshe: A Living Testimony At the heart of the ARVs4Me launch lies the powerful narratives of individuals like Dudu Mdletshe, a Diesploot community member. Dudu\’s challenging, yet rewarding journey now drives her mission to educate her community about HIV testing, awareness, and taking proactive steps towards a healthier future. Diagnosed in 2000, Dudu initially grappled with denial, not expecting her HIV test results to say she was infected with HIV. Determined to confront her reality, Dudu took the HIV test again after a couple of years at a different clinic, receiving the confirmation she needed to begin her journey with HIV. She commenced her treatment in 2008, and has since thrived, embodying the message that HIV is no longer a death sentence. Her story underscores the importance of early testing, acceptance, and the life-changing impact of antiretroviral treatment. Today, Dudu advocates for regular HIV testing, emphasising that an HIV diagnosis should not define one\’s future. “Not only have I accepted my HIV status, but I have over the years told myself not to allow my status to take over my life. I take my HIV treatment as prescribed and make every effort to lead a healthy, fulfilling life. To me, HIV is just another sickness that can be managed with the right treatment”. “In fact,” she chuckles, “I had a conversation with the virus and told it that its place is right at the tip of my toe – it doesn’t and will not rule my world.” Dudu passionately encourages everyone to get tested, emphasising that living with HIV is now manageable, allowing individuals to lead wholesome lives without the burden of excessive medication. Her advocacy aligns with the broader goal of the ARVs4Me campaign: to reshape perceptions around HIV, eradicate stigma, and promote proactive healthcare choices. In Dudu\’s words, \”Today’s HIV-positive patients can expect to live long and happy lives without taking too many pills. HIV should no longer be viewed as a death sentence but as a manageable health condition.\” A Call to Action The initial launch of the ARVs4Me campaign has been met with resounding success, with active participation from communities eager to take charge of their health. Anova will continue to visit areas most in need of these services, ensuring that the campaign\’s impact is felt across diverse populations. Through initiatives like ARVs4Me, Anova Health Institute remains at the forefront of the fight against HIV/AIDS, championing UNAIDS targets and empowering communities to lead the way towards a healthier future. To learn more about HIV care and treatment visit ARVs4Me.co.za.